Volume 27, Issue 2 (Summer-In Press 2026)
jrehab 2026, 27(2): 0-0 |
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Alem M, Khalkhali Zavieh M, khademi-kalantari K, Akbarzadeh Baghban A. Effect of Concurrent Unilateral Transcranial Stimulation of Primary Motor Cortex and Dorsolateral Prefrontal Cortex by Direct Current Stimulation on Tremor: A Case Report Study. jrehab 2026; 27 (2)
URL: http://rehabilitationj.uswr.ac.ir/article-1-3701-en.html
URL: http://rehabilitationj.uswr.ac.ir/article-1-3701-en.html
1- School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Physiotherapy Department, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,minoo_kh@yahoo.com
3- Physiotherapy Department, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Proteomics Research Center, Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Physiotherapy Department, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
3- Physiotherapy Department, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Proteomics Research Center, Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract: (9 Views)
Introduction: Abnormal movements of one or more parts of body during various activities is called tremor which, according to recent studies, is the most common neurodegenerative dysfunction. Transcranial direct current stimulation (tDCS) is one of the non-invasive treatments that increases cortical excitability and is effective in many brain dysfunctions.
Method: The goal of us in this case report study is to investigate the therapeutic effect of the primary motor cortex (M1) stimulation and improve M1 connection with cerebello-thalamo-cortical circuit. . Previous studies have shown that concurrent stimulation of M1 and dorsolateral prefrontal cortex ( DLPFC) has more effective and long-lasting effects. The patient with a right-hand tremor with no defined cause had two sessions of treatment with a one-week interval. In the first session, only M1 and in the second session M1 and DLPFC were stimulated concurrently. Before the first session, after the second session, and one and two months after treatment intensity of the tremor and life quality were measured through Fahn-Tolosa-Marin and Short- Form-12 (SF12), respectively.
Results: After treatment sessions, Fahn-Tolosa-Marin scale (the measure of tremor intensity) decreased from 9 to 1 and SF12 (the measure of life quality) increased from 26 to 40 and these results were the same three-month after treatment showing the stability of treatment effects.
Conclusion: It seems that the proposed treatment was effective and effectively reduced the intensity of tremor and improved the quality of patient’s life.
Method: The goal of us in this case report study is to investigate the therapeutic effect of the primary motor cortex (M1) stimulation and improve M1 connection with cerebello-thalamo-cortical circuit. . Previous studies have shown that concurrent stimulation of M1 and dorsolateral prefrontal cortex ( DLPFC) has more effective and long-lasting effects. The patient with a right-hand tremor with no defined cause had two sessions of treatment with a one-week interval. In the first session, only M1 and in the second session M1 and DLPFC were stimulated concurrently. Before the first session, after the second session, and one and two months after treatment intensity of the tremor and life quality were measured through Fahn-Tolosa-Marin and Short- Form-12 (SF12), respectively.
Results: After treatment sessions, Fahn-Tolosa-Marin scale (the measure of tremor intensity) decreased from 9 to 1 and SF12 (the measure of life quality) increased from 26 to 40 and these results were the same three-month after treatment showing the stability of treatment effects.
Conclusion: It seems that the proposed treatment was effective and effectively reduced the intensity of tremor and improved the quality of patient’s life.
Keywords: Transcranial Direct Current Stimulation (tDCS), Tremor, primary motor cortex (M1), Dorsolateral Prefrontal Cortex (DLPFC)
Type of Study: Case report |
Subject:
Physical Therapy
Received: 2/11/2025 | Accepted: 23/05/2026 | Published: 12/07/2026
Received: 2/11/2025 | Accepted: 23/05/2026 | Published: 12/07/2026
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This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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