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Alem M, Khalkhali Zavieh M, Khademi-Kalantari K, Baghban A A. Effect of Concurrent Transcranial Direct Current Stimulation on the Primary Motor Cortex and Dorsolateral Prefrontal Cortex on Essential Tremor: A Case Report. Arch Rehabil 2026; 27 (2) :366-377
URL: http://rehabilitationj.uswr.ac.ir/article-1-3701-en.html

Objective Abnormal trembling movement in one or more parts of the body during various activities is called tremor, which is one of the most common neurological disorders. Transcranial direct current stimulation (tDCS) is a non-invasive treatment that increases cortical excitability and is effective in treating many brain dysfunctions. Previous studies have shown that concurrent stimulation of the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) has more effective and long-lasting effects. This study reports the therapeutic effects of concurrent tDCS over M1 and DLPFC on tremor severity in an old man with essential tremor (ET).
Materials & Methods The case was a 75-year-old man with right-hand ET during daily activities. He received two sessions of tDCS with a one-week interval. In the first session, only M1 was stimulated, while in the second session, both M1 and DLPFC were stimulated. The tremor severity and quality of life were measured using the Fahn-Tolosa-Marin (FTM) scale and the Short Form Health Survey (SF-12), respectively, before, immediately after, one month after, and two months after treatment.
Results After treatment, the FTM scale score decreased from 9 to 1, and the SF-12 score increased from 26 to 40; these changes were sustained up to 3 months after treatment, indicating the stability of treatment effects. 
Conclusion It seems that the proposed tDCS method is effective in reducing the intensity of tremor and improving the quality of life in older men with ET.