Volume 6, Issue 1 (Spring 2005)                   Vol. , No. , Season & Year , Serial No. | Back to browse issues page

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Najm-Abadi H, Kahrizi K. Review: Hearing Loss Genetics. jrehab. 2005; 6 (1) :48-56
URL: http://rehabilitationj.uswr.ac.ir/article-1-100-en.html
1- University of Welfare & Rehabilitation Siences, Tehran, Iran. , E-mail: kkahrizi@uswr.ac.ir
Abstract:   (9825 Views)

It has been estimated that approximately one in 1000 live births suffer from profound deafness, and greater than 50% of this group is genetic etiology. So far more than 300 different genetic conditions responsible for deafness have been reported that among them 70% are non-syndromic and the rest are syndromic. Non-syndromic and syndromic hearing loss may be divided into Autosomal dominant (DFNA), Autosomal recessive (DFNB), X-linked (DFN), and mitochondrial. Approximately 75-80% are autosomal recessive, 10-20% autosomal dominant, 1-5% X-linked, and 0-2% mitochondrial. To date, 51 DFNA loci, 61 DFNB loci, and 7 DFN loci have been described. Non-syndromic hearing loss is divided into two postlingual and perlingual groups. As a general rule, most autosomal dominant non-syndromic hereditary hearing impaired is postlingual, while autosomal recessive non-syndromic hereditary hearing impaired is prelingual.

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Type of Study: Review | Subject: General
Received: 8/09/2007 | Accepted: 10/10/2015 | Published: 10/10/2015

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