Objective: To screen comorbidity with substance abuse in adolescents. Among different disorders, 3 disorders of attention deficit/hyperactivity disorder (ADHD), conduct disorder, and depression were studied in a sample of Iranian adolescents.  

Materials & Methods: A total of 33 substance abusers, 35 criminal substance abusers, 34 non-substance abusers were selected from Tehran correctional and rehabilitation center for adolescents and 33 normal subjects (girl and boy) were studied from schools of Tehran south using Achenbach youth self-report questionnaire (YSR) (Achenbach, 1991), demographic and history of drug abuse questionnaire (designed by researchers).

Results: There was a significant different regarding attention deficit/hyperactivity disorder between two groups of substance abuser and non-substance abuser, but the difference was not significant between boys and girls. Regarding conduct disorder, there was a significant difference between two sexes. In boys, there was a significant difference between substance abusers and normal groups. In depression disorder, the difference between two sexes was significant regarding boys differences were observed between three groups selected from correctional and rehabilitation center and normal group regarding girls, there was a significant difference between substance abusers with criminals and normal group.

Conclusion: Apparently, these 3 disorders have shown significant difference between two sexes. ADHD pattern was the same in two sexes. There was a significant difference between two sexes with regard to depression and conduct disorder. In both sexes, ADHD was not correlated with substance abuse. The conduct disorder was not related to substance abuse in both sexes and depression disorder was only related to substance abuse in girls. Considering the youth self-report test (YSR), there is a special mental profile for substance abusers, which separates them from non-substance abusers.