Objective: Negative symptoms of schizophrenia are among the major barriers against rehabilitation of such patients and hinder their appropriate communication with others. Using of adjunctive drugs in addition to current treatments may reduce these symptoms. In this research we have discussed the efficacy of Citalopram, Clomipramine and Alprazolam in reducing such symptoms.

Materials & Methods: Forty male, randomly chosen, schizophrenic patients who have been and are hospitalized for life long residential care in Razi psychiatric hospital, had been chosen for a Double-Blind study (CCT) and divided into four groups and treated with 20 mg Citalopram, 0.75 mg Alprazolam, 25 mg Clomipramine and placebo, respectively, in addition to current treatments (typical antipsychosis). After two weeks, there was doubling of foresaid doses, which continued for another two weeks, and then tapered and terminated. Existence and severity of negative symptoms had been measured with the scale of SANS in the beginning and before applying of adjunctive drugs, and then at the end of second week of therapy, and finally at the end of fourth week during these research no side effect had led to distress for patients. Data has been surveyed according to Z and chi-square (X2-test) formula for comparing of variables.

Results: Citalopram, Alprazolam, and Clomipramine have decreased the severity of negative symptoms, respectively, in 80%, 50% and 50% of patients. In the majority of these patients these decrease has been restricted to 20% from baseline. Only Clomipramine could decrease up to 40% in two cases. Mean while, Clomipramine but, generally these drugs were more efficacious on mild to moderate symptoms (grade 1,2 and 3). Decreasing of symptoms were independent of each other and with variable patterns. There was no statistically important difference between aged and non aged patients. No patient in control group had any benefit from placebo.

Conclusion: Treatment with Citalopram, Alprazolam and Clomipramine can result in benefit and decrease of negative. symptoms in schizophrenic patients. In this regard, overally, the lower side effects and pharmacokinetic interactions of Citalopram in comparing with Clomipramine and Alprazolam deserve attention.