Objective: Stress is a complex and individual phenomenon and unseparable part of human life that sometimes causes problems. If human can not be compatible with stress, he will be hurt physically and mentally. tending to be compatible with stress is a positive way that causes health improvement. Therefore, the aim of present study, is evaluation of stress inoculation training effect on stress of nurses within medical-educational centers in Qom.

Materials & Methods: This study was quasi-experimental. 200 nurses were evaluated. We selected 60 nurses with simple random sampling and divided them to experimental & control groups. Instrument was Derogatis stress profile (DSP). All nurses were evaluated with (DSP) before Intervention, then stress inoculation training workshop was implemented for experimental group in 2 days. Two weeks After Intervention both groups (exp. & cont.) were evaluated with DSP questionnaire again. The results were analyzed with Pairedt Test & Independentt Test in both groups before & after Intervention.

Results: The Findings showed that average stress on environmental, personality and emotional dimensions and score of three dimensions hadn't significant difference before Intervention but this difference was significant after Intervention. 

Conclusion: stress inoculation training implementation, affects nurses stress, and it can be applied to improve cares, and also it can promote health and control stress level.