Objective: This Study aimed to investigate the level of personal-social developmental skills in 1-4 years old children with early treated phenylketonuria.

Materials & Methods: This analytic, cross-sectional study has been done on 40 children 1-4 years old referred to clinics of phenylketonuria (PKU) who were diagnosed through screening at birth and were treated. The measurements were a demographic questionnaire, ASQ (Ages & Stages Questionnaire) and clinical assessment by pediatrician. Forty children were also selected randomly as control group from kindergartens of Tehran and completed the questionnaires. Data were analyzed by SPSS 19.0 software.

Results: The mean age of Children was 30.7 (±10.5) months in the control group and 27.7 (±11.0) months in the case groups. There was no significant differences between two groups in terms of delivery type and the current and birth height, weight and head circumference. There was a significant difference between two groups regarding personal-social developmental skills (P<0.001).

Conclusion: The level of personal-social developmental skills in the children with early treated Phenylketonuria is lower than normal children. Early diagnosis and intervention for all children with early treated Phenylketonuria is recommended.

Objective: This research was made to personal- social developmental screening of 4-60 months old children in Tehran city by DDST-II and ASQ and determining the agreement coefficient of two tests.

Materials & Methods: In this study, the personal-social developmental status of 197 children 4-60 months old were screened by using ASQ and PDQ (93 girls and 104 boys). Convenient sampling was used. Data was analyzed by SPSS software.

Results: By using DDST-II and ASQ personal- social developmental delay detected in 11% and 1.5% of children respectively. The estimated consistency coefficient between DDST-II and ASQ for Personal- social domain was 0.06.

Conclusion: In this study personal- social developmental screening of children showed different results and kappa measure agreement of two tests was weak. For selecting a suitable tool we must consider the psychometric characteristics (sensitivity, specificity, positive and negative predicting power) of the tool. This study showed that the results of developmental screening of 4-60 months old children in Tehran by using ASQ and PDQ lead to different results. This finding emphasizes the need to comparing the results of screening tests with a diagnostic gold standard test.