Objective: Having a child with cerebral palsy affected all aspects of quality of life the mothers. This is a Quasi-experimental study which was carried out in order to determine the effects of applying supportive program health-centered on the quality of life of cerebral palsy children’s mothers.

Materials & Methods: This study is a quasi-experimental research with two groups case (n=30) and control (n=30) who were selected by random sampling method. Supportive Programs health-centered for case group performed in three stages (assessment, protection and evaluation). Data collection tools include: demographic questionnaire and quality of life questionnaire. Data collected before and two months after intervention. Statistical analysis was done by spss16 software.

Results: Data analysis with Chi-square showed that demographic data were similar in both groups (P>0.05). Comparison of quality of life after intervention by independent samples t-test was significant in two groups (P<0.05) But in dimensions of social function this difference is not significant (P>0.05). Paired t-test showed that there is a significant difference between mean scores of eight dimensions of QOL and whole QOL before and after study in experimental group (P<0.05) But this difference is not significant in control group (P>0.05).meams difference of whole QOL was significant in Both groups (P<0.05).

Conclusion: According to these findings, applying supportive program health-centered on the quality of life of cerebral palsy children’s mothers is effective. So it is suggested that supportive program health-centered to be applied as an effective method to promotion quality of life of chronic disease children’s mothers. Key words: supportive program health-centered, quality of life, cerebral palsy