Volume 4, Issue 2 (Summer 2003)                   Vol. , No. , Season & Year , Serial No. | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Owhadi M, Fadaei F, Khodayari N, Rahimi A, Najm-Abadi H. Association of the Dopamine Transporter Gene (DAT1) Core Promotor Polymorphism-67T Allele with Schizophrenia. jrehab. 2003; 4 (2) :16-19
URL: http://rehabilitationj.uswr.ac.ir/article-1-605-en.html
1- University of Welfare and Rehabilitation Sciences, Tehran, Iran.
Abstract:   (5242 Views)

Objective: Dysfunction of the central dopaminergic neurotransmission has been suggested to play an important role in the etiology of schizophrenia. The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapses and thereby plays a key role in the regulation of the dopaminergic neurotransmission. In this study, we sought to determine the possible association of the DAT1 gene core promoter polymorphism-67A/T with schizophrenia in a case control study.

Materials & Methods: The allele and genotype frequencies of the polymorphism were studied in 100 patients and 100 controls, which were matched on the basis of sex, age and ethnicity.

Results: The genotype frequencies in the patients group were as follows: AA 29%, AT 59%, TT 12% vs. the genotype frequencies in the control group: AA 57%, AT 38%, TT 5%, IX2=16.54, df-2, OR=2.25 (95%CI1.46-3, 45, P&le0.0003)].

Conclusion: For the first time, these findings provide tentalive evidence for the contribution of the DAT1 gene core promoter polymorphism to the etiopathology of schizophrenia at least in the Iranian male population that we studied. Replication studies of independent samples and family-based association studies are necessary to further evaluate the significance of our findings.

Full-Text [PDF 60 kb]   (967 Downloads)    
Type of Study: Original | Subject: Genetics
Received: 1/09/2010 | Accepted: 18/10/2015 | Published: 18/10/2015

Add your comments about this article : Your username or Email:

© 2018 All Rights Reserved | Archives of Rehabilitation

Designed & Developed by : Yektaweb