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Objective: Work related accidents are considered as a significant health problem of working population. The goal of this study was to determine relation of treatment management with treatment outcome of Work-Related injuries leading to amputation.

Materials & Methods: current study was based on correlation method which was evidence based and was based on actual data of medical records of occupational accidents leading to amputations. Study population included all injuries that suffered limb amputation due to work and were referred to Laleh hospital during 2005 to 2009 (N=135). The data were collected by check list and analyzed by descriptive and inferential Statistics.

Results: Taking care method had a considerable effect on success of replant operation of that limb (P<0.001) so that in 95.23% of injuries whom principles of primary care had been done for them during transportation of amputated limb to hospital, had a successful operation. Treatment results of injuries in large limbs have had a strong relation to interval of incident occurrence to start of operation (P=0.038) How to refer injuries to hospital has not had a meaningful impact on treatment outcome (P=0.469) although referring injuries from health centers of workplace directly to hospital had more successful result comparing to transferring from other hospitals.

Conclusion: Appropriate management of work-related injuries leading to amputation especially primary healthcare’s during limb transmission and reducing transmission time, correct organization of referring procedure can prevent occurrence of many devastating disabilities and horrible consequences.