Objective: Among different epileptic syndrome infantile spasm is one of the most malignant forms which cause irrepairable brain damage in the child. Consequently the longer this type of epilepsy lasts the more harmful results will follow. The majority of children with infantile spasm are younger than one year age and only 5 percent of affected children are in the age group above one year.

Materials & Methods: This descriptive study was done on 60 (36 male and 24 female) infants 2-24 months age with clinical examination, observation, interview and questionnaire  in pediatric neurology department of Mofid children hospital during two years.

Results: From 60 patients (36 male and 24 female), 48 case (80%) symptomatic and 12 case (20%) cryptogenic and idiopathic. Based on clinical manifestation 35 case (58%) were flexor type. 6 case (10%) extensor and 19 cases (32%) mixed. In EEG hypsarrhythmia in all patients was seen. Brain CT scan in 11 cases showed brain atrophy and in remainder was normal.

Conclusion: In our study etiologically symptomatic and clinically flexor type was more common. Hysparrhythmia in all patients was seen and brain CT scan in 80% of patients was normal.