Objective: The aim of this study was to measure of cardiac rehabilitation program (Endurance & Resistance training) effect on physical functioning as well as its exact effect on lipid profile and fasting blood sugar of cardiovascular patients.

Materials & Methods: In this quasi experimental and interventional study 20 patients who arrived to phase II cardiac rehabilitation after their first cardiovascular accident were selected conveniently and participated in this prospective study. Anthropometrics' measurements, FBS and blood lipid, 6–MWT were performed at the beginning and at the end of 8 weeks program (3 days per week for 24 sessions). Data were analyzed by Paired T test.

Results: Except for low–density lipoprotein (LDL) (P=0.087) and FBS (P=0.072), all other biochemical indices [total cholesterol (TC) (P=0.019), high–density lipoprotein (HDL) (P=0.019), and triglyceride (TG) (P=0.009)], functional capacity (6MWT) (P<0.001) and measurment of rate pressure product with Borg scale (P=0.008), and also obesity indices including weight (P=0.031) and subcutaneus fat (P=0.017) had significant response to cardiac rehabilitation program (CRP).

Conclusion: These results support the benefits of cardiac rehabilitation program such as endurance and resistance training to reduce overall risk in obese patients with coronary heart disease, and increase physical capacity.