Volume 7, Issue 4 (Winter 2007)                   Vol. , No. , Season & Year , Serial No. | Back to browse issues page

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Razavi Z, Taghdiri M M. A case Report of Wolfram Syndrome. jrehab. 2007; 7 (4) :75-77
URL: http://rehabilitationj.uswr.ac.ir/article-1-28-en.html
1- Hamedan University of Medical Sciences, Hamedan, Iran. , E-mail: razavizahra@yahoo.com.au
Abstract:   (9841 Views)

Wolfram syndrome is the association of diabetes mellitus, optic atrophy, diabetes insipidus and sensorineural deafness and is sometimes called DIDMOAD (Diabetes Insipidus, Diabets Mellitus, Optic Atrophy, and Deafness). It is a rare autosomal recessive disease with prevalence of one per 770,000. Natural history of Wolfram syndrome suggests that most patients will eventually develop most complications of this progressive neurodegenerative disorder. Juvenile–onset diabetes mellitus and optic atrophy are the best available diagnostic criteria for Wolfram syndrome.

In this report clinical features of a patient with DIDMOAD syndrome is presented. A 12 year old male presented with short standing diabetes mellitus and diabetes insipidus. Further investigations showed bilateral optic atrophy, mild hearing loss and short stature. His parents were relative and he is first case in his family.

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Type of Study: Case report | Subject: General
Received: 30/07/2007 | Accepted: 12/10/2015 | Published: 12/10/2015

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