Gluteal intramuscular injection in newborns and children is one of the most common causes of sciatic palsy. Two factors are important to cause this palsy: kind of injection material and injection side. In this article we reported 28 cases of sciatic palsy (complete or incomplete) after Gluteal region injection of Diclofenac during years of 1389 to 2001 referring to Imam Khomeini hospital. Ten of these patients underwent surgical release that all of them got satisfactory results.