Volume 14 - Special Issue: Pediatric Neurorehabilitation                   Vol. , No. , Season & Year , Serial No. | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sajedi F, Nazi S, Rohani F, Biglarian A. Motor Development Skills of 1- to 4-Year-Old Iranian Children with Early Treated Phenylketonuria. jrehab. 2014; 14 (S2) :100-106
URL: http://rehabilitationj.uswr.ac.ir/article-1-1376-en.html
1- Associate professor USWR
2- PHD student of Occupational therapy Iran University of Medical Sciences, Tehran, Iran. , sepideh.nazi@gmail.com
3- Assistant professor IUMS
4- Assistant professor USWR
Abstract:   (4803 Views)

Objective: To gauge the gross and fine motor development of early treated phenylketonuria (ETPKU) in children in the age range of 1–4 years.

Materials & Methods: A cross-sectional analytic study was conducted in PKU clinics (reference clinics for PKU follow-up), Tehran, Iran. Seventy children with ETPKU were selected as the case group for the study. ETPKU children were those with early and continuous treatment with a phenylalaninerestricted diet (the mean of blood phenylalanine level during the recent 6 months was 2–6 mg/dL or 120–360 mmol/L). Also, 100 healthy and normal children matched with the ETPKU group for age were randomly selected from 4 kindergartens in four parts of Tehran as a control group. The measurements consisted of a demographic questionnaire, Peabody Developmental Motor Scale-2 (PDMS-2), and pediatrician assessment. Motor quotients were determined by PDMS-2 and then compared in both groups by two independent samples t-test.

Results: The mean ages in case and control group were 28.5 (±11.6) and 29.7 (±11.3) months, respectively. Comparison of the mean fine, gross, and total developmental motor quotients (DMQs) showed statistically significant differences between the two groups (P<0.05). The fine and total DMQs of ETPKU children were also correlated with age. In addition, there was a negative correlation between the phenylalanine level and fine (P<0.001) and total (P=0.001) DMQs.

Conclusion: It seems that ETPKU Iranian children, regardless of following a phenylalanine-restricted diet or not, have lower motor development. It is recommended to plan programs for early detection and intervention of developmental delays in these children.  

Full-Text [PDF 392 kb]   (947 Downloads)    
Type of Study: Original | Subject: General
Received: 13/10/2013 | Accepted: 2/03/2014 | Published: 17/03/2014

Add your comments about this article : Your username or Email:
Write the security code in the box

Send email to the article author


© 2018 All Rights Reserved | Archives of Rehabilitation

Designed & Developed by : Yektaweb